Djabu

In July 2007, a new track titled "This Moment" was released on the soundtrack to the film Transformers. Disturbed mixed their fourth studio album, titled Indestructible, in Los Angeles, California in late 2007. In an earlier interview, David Draiman said that they were going to record fifteen songs, but only twelve would be on the album.

On March 6, 2008, the band released a thirty second sample of a newly re-recorded version of the song "Perfect Insanity" on their MySpace profile. In March 2008, the song was made available for full download on the band's website, which led to the song receiving some minor radio airplay, and the band playing it live in Kuwait during a special Operation MySpace event.

Indestructible's first single, "Inside the Fire" was made available on digital distribution services for purchase on March 25, 2008. The band also toured in the United States in April and May 2008 with the bands Five Finger Death Punch and Art of Dying. The music video for "Inside the Fire" was released on May 2, 2008 on the band's official website. Disturbed released their previously free song "Perfect Insanity" on iTunes Store as a second single on May 6, 2008, and the album Indestructible become available for pre-order for the release date on June 3, 2008.

On May 13, 2008, Harmonix, the developers of the video game Rock Band announced they had reached a deal with Disturbed and Best Buy to offer two tracks from Indestructible for play in Rock Band to those who pre-ordered the album from Best Buy's website. On June 3, 2008, Harmonix released three tracks from Indestructible; "Indestructible", "Inside the Fire", and "Perfect Insanity". On May 12, 2009, Harmonix released Stricken and Stupify to the Rock Band music store. Disturbed played their first live online concert on May 29, 2008. The concert was sponsored by Pepsi and Deep Rock Drive. They performed in Las Vegas.

Indestructible was released in the United States on June 3, 2008 and in Australia on June 7, 2008 and became the band's third consecutive number-one debut on the Billboard 200. A special "Internet Only" limited edition of the album that includes the B-side track "Run", a making-of DVD with instructional videos, wrap-around poster, VIP laminate, access to special Disturbed events, and a special website with exclusive video, rare audio and more was also released. The band toured in support of the "Mayhem Festival" alongside DragonForce, Children of bodom and Avenged sevenfold during summer of 2008. Disturbed also completed a tour of Australia and New Zealand through August and September 2008.

On September 30, 2008, the band released an iTunes-exclusive live album entitled Live & Indestructible, made up of songs from Deep Rock Drive, as well as the music video for "Indestructible"^]. The band started a tour of Europe, starting in London during October 2008 and finishing during November 2008 in Helsinki. In November and December 2008, Disturbed toured in the United States. The song "Inside the Fire" was nominated for a 2009 Grammy Award in the "Best Hard Rock Performance" category. In March 2009, Disturbed released a music video for the single "The Night".

The band began their Music as a Weapon IV tour in March 2009 and it ended in late May. The tour, also dubbed a "festival", featured the bands Killswitch Engage, Lacuna Coil, and Chimaira on the main stage. The band released a second cover version of Faith No More's song "Midlife Crisis" on the album Covered, A Revolution in Sound, which also included bands such as Mastodon, The Used, and Avenged Sevenfold. This cover of "Midlife Crisis" was originally recorded for Indestructible, but the band decided not to include it on the album.